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Patent Strategies for Attenuated Pathogen Vaccines

Abstract

Malaria is a major health concern for people traveling to and living in malaria-endemic areas, causing 249 million clinical cases and 608,000 deaths in 2022, numbers essentially unchanged over the past decade. Plasmodium falciparum (Pf) is the eukaryotic parasite that is responsible for the vast majority of these deaths. To date, there is no licensed vaccine available in the United States or European Union that prevents malaria, although two partially effective vaccines, indicated for use in infants and small children, are licensed in some African countries. The World Health Organization has recently called for improved vaccines that at once prevent Pf infection in > 90% of recipients while also blocking transmission from mosquitoes to humans, enabling these vaccines to be used in malaria-elimination campaigns. Sanaria Inc. is developing highly effective, aseptic, live, attenuated Pf vaccines designed to address this need and which also can be used to protect travellers to malaria endemic areas. As Senior Director of Intellectual Property, my job has been to develop strategies for patent protection of these vaccines.

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Author

Portrait image of David Dolberg
David Dolberg
Senior Director of Intellectual Property, Sanaria Inc., USA

David Dolberg, Esq., PhD is Senior director of Intellectual Property for Sanaria Inc. He was formerly with the law firm of Morrison & Foerster, and Director of Intellectual Property for biotech start-ups Erox Corp. and Pherin Corp. He is the first author on papers published in Nature and Science, and a member of the California and US Patent Bars.

Company

Sanaria Inc.

Sanaria is a biotechnology company developing vaccines protective against malaria. Sanaria’s vaccines have proven highly protective against Plasmodium falciparum infection in humans. Sanaria's vaccines are intended to be used to prevent malaria in individuals and, in combination with other malaria control measures, to halt transmission of and eliminate malaria from communities.

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